BENZNIDAZOLE AND AMIODARONE COMBINED TREATMENT ATTENUATES CYTOSKELETAL DAMAGE IN TRYPANOSOMA CRUZI-INFECTED CARDIAC CELLS

Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells

Chagas disease (CD), a Dog Food-Wet neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, is an important public health problem mainly in Latin America, leading to approximately 12,000 annual deaths.Current etiological treatment for CD is limited to two nitro compounds, benznidazole (Bz) and nifurtimox (Nif), both presentin

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Development of a technique to evaluate the performance of cooling headers and its applications in POSCO plate mills

Hundreds of thousands of liquid jet nozzles are widely used in controling cooling equipment to accelerate the cooling of hot plates.The holes of these nozzles become clogged or the Bird Feeders hole size becomes smaller as foreign substances like grease, scrap, and mud containing cooling water are flushed through.In this case, cooling water sprays

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Research on Personalized Recommendation Algorithm Integrating Cross-Grained Sentiment and Rating Interaction Features

To investigate the impact of cross-grained sentiments on user feature representation and address the issue of data sparsity, this paper proposes a Personalized Recommendation Algorithm Integrating Cross-Grained Sentiment and Rating Adjustment Knob Interaction Features (ICSR).The algorithm begins by employing a pre-trained BERT (Bidirectional Encode

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Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer

Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has been a milestone in the history of KRAS mutant tumors; however, therapeutic resistance limits

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